化學療法:烷化劑（Alkylating agents）[]
- 或稱烷基化劑
- alkylation through
- alkylation through carbocation
- alkylation through radical
- alkylation at what position
- interstrand cross-link
- intrastrand cross-link
Nitrogen mustards[]
aliphatic[]
- Nitrogen mustard N-oxide
- mechlorethamine
aromatic[]
- Melphalan
- Chlorambucil → Melphalan
其他[]
- Cyclophosphamide (prodrug of phosphoramide mastard):免疫抑制劑 → phosphoramide mastard
- Ifosfamide (prodrug of ifosfamide mastard)
- Estramustine → Estramustine phosphate
- Estramustine phosphate
- phenoxybenzamine(別和phenbenzamine搞混): 治療pheocromocytoma
Aziridines[]
- Triethylenemelamine → Thiotepa
- Triethylenemelamine → Carboquone ← Mitomycin（Antineoplastics - agents from natural products）
Nitrosoureas : alkylation through carbocation : 常常脂溶性夠大而可以治療中樞神經癌症[]
chloroethylnitrosourea : O6 or N7 -alkylation of guanine nucleoties[]
- Methylnitrosoureas → Carmustine → Nimustine
- Methylnitrosoureas → Iomustine → Nimustine
不知道[]
- Nimustine
- Methylnitrosoureas → Iomustine → Semustine
- Streptozocin → Ranimustine
- Ranimustine
Procarbazine and triazenes: O6-methylation of guanine nucleoties with thymine→MMS(mis match repair system )[]
Procarbazine[]
Procarbazine→diazene intermediate : alkylation through radical
triazenes /Prodrug of MTIC : alkylation through carbocation[]
- Dacarbazine
- imidazolotetrazene der: Temozolomide
Alkyl sulfonate[]
- Busulfan : N7-methylation of guanine nucleoties
organoplatinum/Platinum coordination complex[]
- Cisplatin(生理食鹽水當作溶劑) N7-methylation of guanine nucleoties → Carboplatin → Nedaplatin
- Carboplatin(D5W當作溶劑) intrastrand cross-link between G and G
- Nedaplatin
- Cisplatin → Iproplatin
- Oxaliplatin